• Target：
• Fibulin-3

• Gene Name：
• EFEMP1

• Protein Name：
• EGF-containing fibulin-like extracellular matrix protein 1

• Human Gene Id：
• 2202

• Human Swiss Prot No：
• Q12805

• Mouse Gene Id：
• 216616

• Mouse Swiss Prot No：
• Q8BPB5

• Rat Swiss Prot No：
• O35568

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human EFEMP1. AA range:111-160

• Specificity：
• Fibulin-3 Polyclonal Antibody detects endogenous levels of Fibulin-3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• EFEMP1;FBLN3;FBNL;EGF-containing fibulin-like extracellular matrix protein 1;Extracellular protein S1-5;Fibrillin-like protein;Fibulin-3;FIBL-3

• Observed Band(KD)：
• 55kD

• Background：
• This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009],

• Function：
• alternative products:Experimental confirmation may be lacking for some isoforms,disease:Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600]; also known as malattia leventinese (MLVT OR ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the fibulin family.,similarity:Contains 6 EGF-like domains.,

• Subcellular Location：
• Secreted, extracellular space . Secreted, extracellular space, extracellular matrix . Localizes to the lamina propria underneath the olfactory epithelium. .

• Expression：
• In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.

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