• Target：
• ETO-2

• Gene Name：
• CBFA2T3

• Protein Name：
• Protein CBFA2T3

• Human Gene Id：
• 863

• Human Swiss Prot No：
• O75081

• Mouse Gene Id：
• 12398

• Mouse Swiss Prot No：
• O54972

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MTG16. AA range:261-310

• Specificity：
• ETO-2 Polyclonal Antibody detects endogenous levels of ETO-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CBFA2T3;MTG16;MTGR2;ZMYND4;Protein CBFA2T3;MTG8-related protein 2;Myeloid translocation gene on chromosome 16 protein;hMTG16;Zinc finger MYND domain-containing protein 4

• Molecular Weight(Da)：
• 71kD

• Background：
• This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010],

• Function：
• disease:A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.,function:Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486).,induction:Down-regulated by all-trans retinoic acid.,similarity:Belongs to the CBFA2T family.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 1 TAFH (NHR1) domain.,subcellular location:The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.,subunit:Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity). Heterodimer with RUNX1T1 and CBFA2T2. Interacts with ERBB4,

• Subcellular Location：
• [Isoform 1]: Nucleus, nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.; [Isoform 2]: Nucleus, nucleoplasm . Golgi apparatus membrane .

• Expression：
• Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).

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