ERCC4 Polyclonal Antibody

    • Catalog No.：YT1615
    • Applications：WB;ELISA
    • Reactivity：Human;Mouse
      • Target：
      • ERCC4
      • Fields：
      • >>Nucleotide excision repair;>>Fanconi anemia pathway
      • Gene Name：
      • ERCC4
      • Protein Name：
      • DNA repair endonuclease XPF
      • Human Gene Id：
      • 2072
      • Human Swiss Prot No：
      • Q92889
      • Mouse Swiss Prot No：
      • Q9QZD4
      • Immunogen：
      • The antiserum was produced against synthesized peptide derived from human XPF. AA range:801-850
      • Specificity：
      • ERCC4 Polyclonal Antibody detects endogenous levels of ERCC4 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • ERCC4;ERCC11;XPF;DNA repair endonuclease XPF;DNA excision repair protein ERCC-4;DNA repair protein complementing XP-F cells;Xeroderma pigmentosum group F-complementing protein
      • Observed Band(KD)：
      • 103kD
      • Background：
      • The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009],
      • Function：
      • cofactor:Magnesium.,disease:Defects in ERCC4 are a cause of XFE progeroid syndrome [MIM:610965]. This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly.,disease:Defects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F) [MIM:278760]; also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities.,function:Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.,similarity:Belongs to the XPF family.,subunit:Heterodimer composed of ERCC1 and XPF/ERCC4. Interacts with EME1.,
      • Subcellular Location：
      • Nucleus . Chromosome . Localizes to sites of DNA damage. .
      • Expression：
      • Epithelium,Fibroblast,
      • Products Images
      • Western Blot analysis of various cells using ERCC4 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
      • Western Blot analysis of 293 cells using ERCC4 Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
      • Western blot analysis of lysates from 293 cells, using XPF Antibody. The lane on the right is blocked with the synthesized peptide.

      Attributes

      • Code：
      • YT1615
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-07-19
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