• Target：
• EDG-3

• Fields：
• >>Sphingolipid signaling pathway;>>Neuroactive ligand-receptor interaction

• Gene Name：
• S1PR3

• Protein Name：
• Sphingosine 1-phosphate receptor 3

• Human Gene Id：
• 1903

• Human Swiss Prot No：
• Q99500

• Mouse Gene Id：
• 13610

• Mouse Swiss Prot No：
• Q9Z0U9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human EDG3. AA range:115-164

• Specificity：
• EDG-3 Polyclonal Antibody detects endogenous levels of EDG-3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• S1PR3;EDG3;Sphingosine 1-phosphate receptor 3;S1P receptor 3;S1P3;Endothelial differentiation G-protein coupled receptor 3;Sphingosine 1-phosphate receptor Edg-3;S1P receptor Edg-3

• Observed Band(KD)：
• 42kD

• Background：
• This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008],

• Function：
• function:Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.

Hyperglycemia‐Triggered Sphingosine‐1‐Phosphate and Sphingosine‐1‐Phosphate Receptor 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization. LIVER TRANSPLANTATION Liver Transplant. 2019 Jul;25(7):1074-1090 WB Mouse 1:100 Liver

Salidroside Inhibits CCl4-Induced Liver Fibrosis in Mice by Reducing Activation and Migration of HSC Induced by Liver Sinusoidal Endothelial Cell-Derived Exosomal SphK1. Frontiers in Pharmacology Front Pharmacol. 2021 May;0:1195 WB Mouse，Human Liver，serum exosomes

Yuan Chang, Hu, et al. "Hyperglycemia Triggered S1P/S1PR3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization." Chao and Yang, Shikun and Cheng, Xuyu and Cheng, Feng and Rao, Jianhua and Wang, Xue-Hao, Hyperglycemia Triggered S1P/S1PR3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M 1 (2018).

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