• Target：
• DUS2L

• Gene Name：
• DUS2L

• Protein Name：
• tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

• Human Gene Id：
• 54920

• Human Swiss Prot No：
• Q9NX74

• Mouse Gene Id：
• 66369

• Mouse Swiss Prot No：
• Q9D7B1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human DUS2L. AA range:421-470

• Specificity：
• DUS2L Polyclonal Antibody detects endogenous levels of DUS2L protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DUS2L;DUS2;tRNA-dihydrouridine(20) synthase [NAD(P)+]-like;Up-regulated in lung cancer protein 8;URLC8;tRNA-dihydrouridine synthase 2-like;hDUS2

• Observed Band(KD)：
• 55kD

• Background：
• dihydrouridine synthase 2(DUS2) Homo sapiens This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012],

• Function：
• cofactor:FAD.,function:Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.,similarity:Belongs to the dus family. Dus2 subfamily.,similarity:Contains 1 DRBM (double-stranded RNA-binding) domain.,subcellular location:Mainly at the endoplasmic reticulum.,subunit:Interacts with EPRS.,tissue specificity:Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).,

• Subcellular Location：
• Cytoplasm . Endoplasmic reticulum . Mainly at the endoplasmic reticulum. .

• Expression：
• Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).

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