• Target：
• DOC-1

• Gene Name：
• CDK2AP1

• Protein Name：
• Cyclin-dependent kinase 2-associated protein 1

• Human Gene Id：
• 8099

• Human Swiss Prot No：
• O14519

• Mouse Gene Id：
• 13445

• Mouse Swiss Prot No：
• O35207

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CDKAP1. AA range:51-100

• Specificity：
• DOC-1 Polyclonal Antibody detects endogenous levels of DOC-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CDK2AP1;CDKAP1;DOC1;Cyclin-dependent kinase 2-associated protein 1;CDK2-associated protein 1;Deleted in oral cancer 1;DOC-1;Putative oral cancer suppressor

• Observed Band(KD)：
• 20kD

• Background：
• cyclin dependent kinase 2 associated protein 1(CDK2AP1) Homo sapiens The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],

• Function：
• similarity:Belongs to the CDK2AP family.,

• Subcellular Location：
• nucleus,perinuclear region of cytoplasm,

• Expression：
• Skin,Testis,

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