• Target：
• DGK-ζ

• Fields：
• >>Glycerolipid metabolism;>>Glycerophospholipid metabolism;>>Metabolic pathways;>>Phosphatidylinositol signaling system;>>Phospholipase D signaling pathway;>>Choline metabolism in cancer

• Gene Name：
• DGKZ

• Protein Name：
• Diacylglycerol kinase zeta

• Human Gene Id：
• 8525

• Human Swiss Prot No：
• Q13574

• Mouse Swiss Prot No：
• Q80UP3

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human DGKZ. AA range:601-650

• Specificity：
• DGK-ζ Polyclonal Antibody detects endogenous levels of DGK-ζ protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DGKZ;DAGK6;Diacylglycerol kinase zeta;DAG kinase zeta;Diglyceride kinase zeta;DGK-zeta

• Molecular Weight(Da)：
• 124kD

• Background：
• The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010],

• Function：
• catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.,PTM:Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.,similarity:Belongs to the eukaryotic diacylglycerol kinase family.,similarity:Contains 1 DAGKc domain.,similarity:Contains 2 ANK repeats.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS.,tissue speci

• Subcellular Location：
• Nucleus . Cytoplasm, cytosol . Cell membrane . Cell projection, lamellipodium .

• Expression：
• Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. ; [Isoform 2]: Predominantly expressed in muscle.

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