• Target：
• cPLA2-ε

• Fields：
• >>Glycerophospholipid metabolism;>>Ether lipid metabolism;>>Arachidonic acid metabolism;>>Linoleic acid metabolism;>>alpha-Linolenic acid metabolism;>>Metabolic pathways;>>MAPK signaling pathway;>>Ras signaling pathway;>>Phospholipase D signaling pathway;>>Necroptosis;>>Vascular smooth muscle contraction;>>VEGF signaling pathway;>>Platelet activation;>>Fc epsilon RI signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Glutamatergic synapse;>>Serotonergic synapse;>>Long-term depression;>>Inflammatory mediator regulation of TRP channels;>>GnRH signaling pathway;>>Ovarian steroidogenesis;>>Oxytocin signaling pathway;>>Choline metabolism in cancer

• Gene Name：
• PLA2G4E

• Protein Name：
• Cytosolic phospholipase A2 epsilon

• Human Gene Id：
• 123745

• Human Swiss Prot No：
• Q3MJ16

• Mouse Swiss Prot No：
• Q50L42

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PLA2G4E. AA range:401-450

• Specificity：
• cPLA2-ε Polyclonal Antibody detects endogenous levels of cPLA2-ε protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PLA2G4E;Cytosolic phospholipase A2 epsilon;cPLA2-epsilon;Phospholipase A2 group IVE

• Molecular Weight(Da)：
• 96kD

• Background：
• catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,domain:The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).,enzyme regulation:Stimulated by cytosolic Ca(2+).,function:Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PLA2c domain.,subcellular location:Translocates to lysosomal membranes in a calcium-dependent fashion.,

• Function：
• catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.,domain:The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).,enzyme regulation:Stimulated by cytosolic Ca(2+).,function:Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PLA2c domain.,subcellular location:Translocates to lysosomal membranes in a calcium-dependent fashion.,

• Subcellular Location：
• Cytoplasm, cytosol . Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein; Cytoplasmic side . Targeted to clathrin-independent endocytotic vesicles through binding to phosphoinositides, especially phosphatidylinositol 4,5-bisphosphates. .

• Expression：
• Heart,Lung,Tongue,

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