• Target：
• COX4I2

• Fields：
• >>Oxidative phosphorylation;>>Metabolic pathways;>>Cardiac muscle contraction;>>Thermogenesis;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy

• Gene Name：
• COX4I2

• Protein Name：
• Cytochrome c oxidase subunit 4 isoform 2 mitochondrial

• Human Gene Id：
• 84701

• Human Swiss Prot No：
• Q96KJ9

• Mouse Gene Id：
• 84682

• Mouse Swiss Prot No：
• Q91W29

• Rat Gene Id：
• 84683

• Rat Swiss Prot No：
• Q91Y94

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human COX42. AA range:31-80

• Specificity：
• COX4I2 Polyclonal Antibody detects endogenous levels of COX4I2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• COX4I2;COX4L2;Cytochrome c oxidase subunit 4 isoform 2; mitochondrial;Cytochrome c oxidase subunit IV isoform 2;COX IV-2

• Observed Band(KD)：
• 20kD

• Background：
• Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008],

• Function：
• function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase IV family.,tissue specificity:Highly expressed in lung.,

• Subcellular Location：
• Mitochondrion inner membrane ; Single-pass membrane protein .

• Expression：
• Highly expressed in lung.

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