• Target：
• COX11

• Fields：
• >>Oxidative phosphorylation;>>Metabolic pathways;>>Thermogenesis

• Gene Name：
• COX11

• Protein Name：
• Cytochrome c oxidase assembly protein COX11 mitochondrial

• Human Gene Id：
• 1353

• Human Swiss Prot No：
• Q9Y6N1

• Mouse Gene Id：
• 69802

• Mouse Swiss Prot No：
• Q6P8I6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human COX11. AA range:51-100

• Specificity：
• COX11 Polyclonal Antibody detects endogenous levels of COX11 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• COX11;Cytochrome c oxidase assembly protein COX11; mitochondrial

• Observed Band(KD)：
• 31kD

• Background：
• Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to c

• Function：
• function:Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.,similarity:Belongs to the COX11/ctaG family.,subunit:Interacts with CNNM4/ACDP4.,tissue specificity:Ubiquitous.,

• Subcellular Location：
• Mitochondrion inner membrane ; Single-pass membrane protein ; Intermembrane side .

• Expression：
• Ubiquitous.

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