• Target：
• Contactin 6

• Gene Name：
• CNTN6

• Protein Name：
• Contactin-6

• Human Gene Id：
• 27255

• Human Swiss Prot No：
• Q9UQ52

• Mouse Gene Id：
• 53870

• Mouse Swiss Prot No：
• Q9JMB8

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CNTN6. AA range:331-380

• Specificity：
• Contactin 6 Polyclonal Antibody detects endogenous levels of Contactin 6 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CNTN6;Contactin-6;Neural recognition molecule NB-3;hNB-3

• Molecular Weight(Da)：
• 114kD

• Background：
• The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

• Function：
• function:Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.,similarity:Belongs to the immunoglobulin superfamily. Contactin family.,similarity:Contains 4 fibronectin type-III domains.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.,

• Subcellular Location：
• Cell membrane ; Lipid-anchor, GPI-anchor .

• Expression：
• Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.

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