• Target：
• Connexin 47

• Gene Name：
• GJC2

• Protein Name：
• Gap junction gamma-2 protein

• Human Gene Id：
• 57165

• Human Swiss Prot No：
• Q5T442

• Mouse Swiss Prot No：
• Q8BQU6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CXG2. AA range:21-70

• Specificity：
• Connexin 47 Polyclonal Antibody detects endogenous levels of Connexin 47 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GJC2;GJA12;Gap junction gamma-2 protein;Connexin-46.6;Cx46.6;Connexin-47;Cx47;Gap junction alpha-12 protein

• Observed Band(KD)：
• 47kD

• Background：
• This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1. [provided by RefSeq, Jul 2008],

• Function：
• caution:It is uncertain whether Met-1 or Met-4 is the initiator.,disease:Defects in GJC2 are the cause of Leukodystrophy hypomyelinating type 2 (HLD2) [MIM:608804]; also known as Pelizaeus-Merzbacher-like disease autosomal recessive type 1. HLD2 is an autosomal recessive hypomyelinating leukodystrophy characterized by nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria and progressive spasticity.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.,similarity:Belongs to the connexin family. Gamma-type subfamily.,subunit:A connexon is composed of a hexamer of connexins. Interacts with TJP1.,tissue specificity:Expressed in central nervous system,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

• Expression：
• Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles.

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