• Target：
• Connexin-45

• Gene Name：
• GJC1

• Protein Name：
• Gap junction gamma-1 protein

• Human Gene Id：
• 10052

• Human Swiss Prot No：
• P36383

• Mouse Gene Id：
• 14615

• Mouse Swiss Prot No：
• P28229

• Rat Gene Id：
• 266706

• Rat Swiss Prot No：
• A4GG66

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human GJC1. AA range:231-280

• Specificity：
• Connexin 45 Polyclonal Antibody detects endogenous levels of Connexin 45 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GJC1;GJA7;Gap junction gamma-1 protein;Connexin-45;Cx45;Gap junction alpha-7 protein

• Observed Band(KD)：
• 45kD

• Background：
• This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008],

• Function：
• function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.,similarity:Belongs to the connexin family. Gamma-type subfamily.,subunit:A connexon is composed of a hexamer of connexins.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

• Expression：
• Testis,Uterus,

Tbx18 promoted the conversion of human-induced pluripotent stem cell-derived cardiomyocytes into sinoatrial node-like pacemaker cells. CELL BIOLOGY INTERNATIONAL Cell Biol Int. 2022 Mar;46(3):403-414 WB Human Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

Cadherin-5 facilitated the differentiation of human induced pluripotent stem cells into sinoatrial node-like pacemaker cells by regulating β-catenin JOURNAL OF CELLULAR PHYSIOLOGY Wei Zhang IF Human 1:200 human induced pluripotent stem cells (hiPSCs)

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