• Target：
• c-Myc

• Fields：
• >>MAPK signaling pathway;>>ErbB signaling pathway;>>Cell cycle;>>PI3K-Akt signaling pathway;>>Cellular senescence;>>Wnt signaling pathway;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>JAK-STAT signaling pathway;>>Thyroid hormone signaling pathway;>>Salmonella infection;>>Hepatitis C;>>Hepatitis B;>>Human cytomegalovirus infection;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Chemical carcinogenesis - receptor activation;>>Colorectal cancer;>>Endometrial cancer;>>Thyroid cancer;>>Bladder cancer;>>Chronic myeloid leukemia;>>Acute myeloid leukemia;>>Small cell lung cancer;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer;>>Central carbon metabolism in cancer

• Gene Name：
• MYC

• Protein Name：
• Myc proto-oncogene protein

• Human Gene Id：
• 4609

• Human Swiss Prot No：
• P01106

• Mouse Gene Id：
• 17869

• Mouse Swiss Prot No：
• P01108

• Rat Gene Id：
• 24577

• Rat Swiss Prot No：
• P09416

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MYC. AA range:386-435

• Specificity：
• c-Myc Polyclonal Antibody detects endogenous levels of c-Myc protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MYC;BHLHE39;Myc proto-oncogene protein;Class E basic helix-loop-helix protein 39;bHLHe39;Proto-oncogene c-Myc;Transcription factor p64

• Observed Band(KD)：
• 50,(also ~60KD in some samples)

• Background：
• The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],

• Function：
• disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.,disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.,function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.,online information:Myc entry,PTM:Phosphorylated by PRKDC.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.,

• Subcellular Location：
• Nucleus, nucleoplasm . Nucleus, nucleolus .

• Expression：
• Cervix,Epithelium,Leukemia,Placenta,Promyelocytic l

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