• Target：
• Claudin-2

• Fields：
• >>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C

• Gene Name：
• CLDN2

• Protein Name：
• Claudin-2

• Human Gene Id：
• 9075

• Human Swiss Prot No：
• P57739

• Mouse Gene Id：
• 12738

• Mouse Swiss Prot No：
• O88552

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Claudin 2. AA range:181-230

• Specificity：
• Claudin-2 Polyclonal Antibody detects endogenous levels of Claudin-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CLDN2;PSEC0059;SP82;Claudin-2;SP82

• Observed Band(KD)：
• 25kD

• Background：
• This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],

• Function：
• function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,

• Subcellular Location：
• Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .

• Expression：
• Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,

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