• Target：
• CHP2

• Gene Name：
• CHP2

• Protein Name：
• Calcineurin B homologous protein 2

• Human Gene Id：
• 63928

• Human Swiss Prot No：
• O43745

• Mouse Swiss Prot No：
• Q9D869

• Rat Gene Id：
• 308965

• Rat Swiss Prot No：
• Q810D1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CHP2. AA range:101-150

• Specificity：
• CHP2 Polyclonal Antibody detects endogenous levels of CHP2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CHP2;HCA520;Calcineurin B homologous protein 2;Hepatocellular carcinoma-associated antigen 520

• Observed Band(KD)：
• 22kD

• Background：
• This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013],

• Function：
• function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death.,similarity:Contains 4 EF-hand domains.,subunit:Binds to SLC9A1/NHE1.,tissue specificity:Expressed in malignantly transformed cells but not detected in normal tissues.,

• Subcellular Location：
• Nucleus . Cytoplasm . Cell membrane . Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. .

• Expression：
• Expressed in malignantly transformed cells but not detected in normal tissues.

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