• Target：
• ChemR23

• Gene Name：
• CMKLR1

• Protein Name：
• Chemokine-like receptor 1

• Human Gene Id：
• 1240

• Human Swiss Prot No：
• Q99788

• Mouse Gene Id：
• 14747

• Mouse Swiss Prot No：
• P97468

• Rat Swiss Prot No：
• O35786

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CMKLR1. AA range:221-270

• Specificity：
• ChemR23 Polyclonal Antibody detects endogenous levels of ChemR23 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CMKLR1;CHEMR23;DEZ;Chemokine-like receptor 1;G-protein coupled receptor ChemR23;G-protein coupled receptor DEZ

• Observed Band(KD)：
• 42kD

• Background：
• developmental stage:Expressed during bone development.,function:Orphan receptor. Could be a chemotactic peptide receptor. May have a function in bone metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands.,

• Function：
• developmental stage:Expressed during bone development.,function:Orphan receptor. Could be a chemotactic peptide receptor. May have a function in bone metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands.,

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein . Internalizes efficiently in response to RARRES2. .

• Expression：
• Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.

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