• Target：
• CDHF10

• Gene Name：
• CELSR2

• Protein Name：
• Cadherin EGF LAG seven-pass G-type receptor 2

• Human Gene Id：
• 1952

• Human Swiss Prot No：
• Q9HCU4

• Mouse Swiss Prot No：
• Q9R0M0

• Rat Swiss Prot No：
• Q9QYP2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CELSR2. AA range:2781-2830

• Specificity：
• CDHF10 Polyclonal Antibody detects endogenous levels of CDHF10 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CELSR2;CDHF10;EGFL2;KIAA0279;MEGF3;Cadherin EGF LAG seven-pass G-type receptor 2;Cadherin family member 10;Epidermal growth factor-like protein 2;EGF-like protein 2;Flamingo homolog 3;Multiple epidermal growth factor-like domains

• Molecular Weight(Da)：
• 317kD

• Background：
• The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008],

• Function：
• function:Receptor that may have an important role in cell/cell signaling during nervous system formation.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 laminin EGF-like domain.,similarity:Contains 2 laminin G-like domains.,similarity:Contains 7 EGF-like domains.,similarity:Contains 9 cadherin domains.,tissue specificity:Highest expression in brain and testis.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Highest expression in brain and testis.

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