• Target：
• CdcA3

• Gene Name：
• CDCA3

• Protein Name：
• Cell division cycle-associated protein 3

• Human Gene Id：
• 83461

• Human Swiss Prot No：
• Q99618

• Mouse Gene Id：
• 14793

• Mouse Swiss Prot No：
• Q99M54

• Rat Gene Id：
• 297594

• Rat Swiss Prot No：
• Q68FW2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CDCA3. AA range:219-268

• Specificity：
• CdcA3 Polyclonal Antibody detects endogenous levels of CdcA3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CDCA3;C8;GRCC8;TOME1;Cell division cycle-associated protein 3;Gene-rich cluster protein C8;Trigger of mitotic entry protein 1;TOME-1

• Observed Band(KD)：
• 28kD

• Background：
• domain:The KEN box is required for the association with the APC/C-Cdh1 complex.,function:F-box-like protein which is required for entry into mitosis. Acts by participating to E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Ubiquitinated and degraded by the APC/C-Cdh1 complex.,subunit:Interacts with SKP1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex.,

• Function：
• domain:The KEN box is required for the association with the APC/C-Cdh1 complex.,function:F-box-like protein which is required for entry into mitosis. Acts by participating to E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Ubiquitinated and degraded by the APC/C-Cdh1 complex.,subunit:Interacts with SKP1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex.,

• Subcellular Location：
• Cytoplasm, cytosol .

• Expression：
• Brain,Placenta,Testis,Thymus,

Suppression of CDCA3 inhibits prostate cancer progression via NF‑κB/cyclin D1 signaling inactivation and p21 accumulation. ONCOLOGY REPORTS Oncol Rep. 2022 Feb;47(2):1-10 WB Human 1:1000 Prostate cancer tissue,paracancerous tissue.

Prognostic value of cell division cycle-associated protein-3 in prostate cancer. MEDICINE Meilin Li IHC Human 1:150 prostate cancer (PCa) tissue

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