CD85c Polyclonal Antibody

  • Catalog No.：YT0780
  • Applications：IHC;IF;ELISA
  • Reactivity：Human
    • Target：
    • CD85c
    • Fields：
    • >>Osteoclast differentiation;>>B cell receptor signaling pathway
    • Gene Name：
    • LILRB5
    • Protein Name：
    • Leukocyte immunoglobulin-like receptor subfamily B member 5
    • Human Swiss Prot No：
    • O75023
    • Immunogen：
    • Synthesized peptide derived from the Internal region of human CD85c.
    • Specificity：
    • CD85c Polyclonal Antibody detects endogenous levels of CD85c protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • IHC 1:100 - 1:300. ELISA: 1:40000. IF 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • LILRB5;LIR8;Leukocyte immunoglobulin-like receptor subfamily B member 5;CD85 antigen-like family member C;Leukocyte immunoglobulin-like receptor 8;LIR-8;CD antigen CD85c
    • Molecular Weight(Da)：
    • 64kD
    • Background：
    • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
    • Function：
    • domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:May act as receptor for class I MHC antigens.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected in a natural killer (NK) cells.,
    • Subcellular Location：
    • Membrane; Single-pass type I membrane protein.
    • Expression：
    • Detected in a natural killer (NK) cells.

    Attributes

    • Code：
    • YT0780
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-07-29
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