• Target：
• CD71/TfR

• Fields：
• >>HIF-1 signaling pathway;>>Endocytosis;>>Phagosome;>>Ferroptosis;>>Hematopoietic cell lineage

• Gene Name：
• TFRC

• Protein Name：
• Transferrin receptor protein 1

• Human Gene Id：
• 7037

• Human Swiss Prot No：
• P02786

• Mouse Gene Id：
• 22042

• Mouse Swiss Prot No：
• Q62351

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CD71/TfR. AA range:15-64

• Specificity：
• CD71 Polyclonal Antibody detects endogenous levels of CD71 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TFRC;Transferrin receptor protein 1;TR;TfR;TfR1;Trfr;T9;p90;CD antigen CD71

• Observed Band(KD)：
• 89kD

• Background：
• This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],

• Function：
• function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use t

• Subcellular Location：
• Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .; [Transferrin receptor protein 1, serum form]: Secreted .

• Expression：
• Brain,Epithelium,Erythroleukemia,Eye,Human endometrium carcinoma cell line,Liver,Pl

Berberine hydrochloride alleviates imatinib mesylate – induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis Food & Function Jie Zhang WB Rat H9c2 cells

IGF2BP2 promotes colorectal cancer progression by upregulating the expression of TFRC and enhancing iron metabolism Biology Direct Kun Yang IHC Human Colorectal cancer (CRC) tissue

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