CD3-ε Polyclonal Antibody

  • Catalog No.：YT0761
  • Applications：WB;IHC;IF;ELISA
  • Reactivity：Human;Rat;Mouse;Monkey
    • Target：
    • CD3E
    • Fields：
    • >>Hematopoietic cell lineage;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>Chagas disease;>>Measles;>>Human T-cell leukemia virus 1 infection;>>Epstein-Barr virus infection;>>Human immunodeficiency virus 1 infection;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Primary immunodeficiency
    • Gene Name：
    • CD3E
    • Protein Name：
    • T-cell surface glycoprotein CD3 epsilon chain
    • Human Gene Id：
    • 916
    • Human Swiss Prot No：
    • P07766
    • Mouse Swiss Prot No：
    • P22646
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from human CD3-epsilon. AA range:22-71
    • Specificity：
    • CD3-ε Polyclonal Antibody detects endogenous levels of CD3-ε protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • CD3E;T3E;T-cell surface glycoprotein CD3 epsilon chain;T-cell surface antigen T3/Leu-4 epsilon chain;CD antigen CD3e
    • Observed Band(KD)：
    • 21kD
    • Background：
    • The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008],
    • Function：
    • function:The CD3 complex mediates signal transduction.,online information:CD3E mutation db,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,similarity:Contains 1 ITAM domain.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.,
    • Subcellular Location：
    • Cell membrane ; Single-pass type I membrane protein .
    • Expression：
    • Blood,T-cell,

    Attributes

    • Code：
    • YT0761
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-22
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