• Target：
• CD137L

• Fields：
• >>Cytokine-cytokine receptor interaction

• Gene Name：
• TNFSF9

• Protein Name：
• Tumor necrosis factor ligand superfamily member 9

• Human Gene Id：
• 8744

• Human Swiss Prot No：
• P41273

• Mouse Swiss Prot No：
• P41274

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TNFSF9. AA range:31-80

• Specificity：
• CD137L Polyclonal Antibody detects endogenous levels of CD137L protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TNFSF9;Tumor necrosis factor ligand superfamily member 9;4-1BB ligand;4-1BBL

• Observed Band(KD)：
• 23kD

• Background：
• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided b

• Function：
• function:Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer .,tissue specificity:Expressed in brain, placenta, lung, skeletal muscle and kidney.,

• Subcellular Location：
• Membrane; Single-pass type II membrane protein.

• Expression：
• Expressed in brain, placenta, lung, skeletal muscle and kidney.

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