Cathepsin D Polyclonal Antibody

  • Catalog No.：YT0681
  • Applications：WB;IHC;IF;ELISA
  • Reactivity：Human;Rat;Mouse;
    • Target：
    • Cathepsin D
    • Fields：
    • >>Sphingolipid signaling pathway;>>Autophagy - animal;>>Lysosome;>>Apoptosis;>>Estrogen signaling pathway;>>Tuberculosis;>>Diabetic cardiomyopathy
    • Gene Name：
    • CTSD
    • Protein Name：
    • Cathepsin D
    • Human Gene Id：
    • 1509
    • Human Swiss Prot No：
    • P07339
    • Mouse Swiss Prot No：
    • P18242
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from human Cathepsin D. AA range:296-345
    • Specificity：
    • Cathepsin D Polyclonal Antibody detects endogenous levels of Cathepsin D protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • CTSD;CPSD;Cathepsin D
    • Observed Band(KD)：
    • 46,30kD
    • Background：
    • This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015],
    • Function：
    • catalytic activity:Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.,disease:Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults, characterized by visual and mental decline, motor disturbance, epilepsy and behavioral changes.,function:Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.,polymorphism:The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for de
    • Subcellular Location：
    • Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). .
    • Expression：
    • Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).

    Attributes

    • Code：
    • YT0681
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-22
    Order

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