• Target：
• Carbonyl Reductase 3

• Fields：
• >>Arachidonic acid metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Metabolic pathways

• Gene Name：
• CBR3

• Protein Name：
• Carbonyl reductase [NADPH] 3

• Human Gene Id：
• 874

• Human Swiss Prot No：
• O75828

• Mouse Gene Id：
• 109857

• Mouse Swiss Prot No：
• Q8K354

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CBR3. AA range:151-200

• Specificity：
• Carbonyl Reductase 3 Polyclonal Antibody detects endogenous levels of Carbonyl Reductase 3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CBR3;Carbonyl reductase [NADPH] 3;NADPH-dependent carbonyl reductase 3

• Observed Band(KD)：
• 31kD

• Background：
• Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.

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