• Target：
• BST-1

• Fields：
• >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Salivary secretion;>>Pancreatic secretion

• Gene Name：
• BST1

• Protein Name：
• ADP-ribosyl cyclase 2

• Human Gene Id：
• 683

• Human Swiss Prot No：
• Q10588

• Mouse Gene Id：
• 12182

• Mouse Swiss Prot No：
• Q64277

• Rat Gene Id：
• 81506

• Rat Swiss Prot No：
• Q63072

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human BST1. AA range:71-120

• Specificity：
• BST-1 Polyclonal Antibody detects endogenous levels of BST-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• BST1;ADP-ribosyl cyclase 2;Bone marrow stromal antigen 1;BST-1;Cyclic ADP-ribose hydrolase 2;cADPr hydrolase 2;CD antigen CD157

• Observed Band(KD)：
• 34kD

• Background：
• Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,disease:Rheumatoid arthritis (RA) patients show enhanced expression of BST-1 transcripts in bone marrow stromal cell lines. This suggests that BST-1 overexpression may play a role in B-cell abnormalities in RA.,function:Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.,similarity:Belongs to the ADP-ribosyl cyclase family.,subunit:Homodimer.,tissue specificity:Widely expressed.,

• Subcellular Location：
• Cell membrane; Lipid-anchor, GPI-anchor.

• Expression：
• Widely expressed.

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