• Target：
• BRCAA1

• Gene Name：
• ARID4B

• Protein Name：
• AT-rich interactive domain-containing protein 4B

• Human Gene Id：
• 51742

• Human Swiss Prot No：
• Q4LE39

• Mouse Gene Id：
• 94246

• Mouse Swiss Prot No：
• A2CG63

• Rat Gene Id：
• 84481

• Rat Swiss Prot No：
• Q9JKB5

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human BRCAA1. AA range:761-810

• Specificity：
• BRCAA1 Polyclonal Antibody detects endogenous levels of BRCAA1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ARID4B;BRCAA1;RBBP1L1;RBP1L1;SAP180;AT-rich interactive domain-containing protein 4B;ARID domain-containing protein 4B;180 kDa Sin3-associated polypeptide;Sin3-associated polypeptide p180;Breast cancer-associated antigen BRCAA1;Hi

• Observed Band(KD)：
• 148kD

• Background：
• This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008],

• Function：
• domain:The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.,domain:The C-terminus mediates interaction with mSin3A corepressor complex.,domain:The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.,function:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,similarity:Contains 1 ARID domain.,subcellular location:Cytoplasmic in breast cancer cells.,subunit:Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.,tissue specificity:Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.,

• Subcellular Location：
• Nucleus . Cytoplasm . Cytoplasmic in breast cancer cells. .

• Expression：
• Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.

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