• Target：
• BMP-8

• Fields：
• >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Thermogenesis

• Gene Name：
• BMP8A/BMP8B

• Protein Name：
• Bone morphogenetic protein 8A/B

• Human Gene Id：
• 656

• Human Swiss Prot No：
• P34820/Q7Z5Y6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human BMP-8. AA range:41-90

• Specificity：
• BMP-8 Polyclonal Antibody detects endogenous levels of BMP-8 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• BMP8B;BMP8;Bone morphogenetic protein 8B;BMP-8;BMP-8B;Osteogenic protein 2;OP-2;BMP8A;Bone morphogenetic protein 8A;BMP-8A

• Molecular Weight(Da)：
• 45kD

• Background：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],

• Function：
• function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 8b entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,

• Subcellular Location：
• Secreted .

• Expression：
• Hippocampus,Testis,

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