BMP-7 Polyclonal Antibody

    • Catalog No.:YT0503
    • Applications:WB;IHC;IF;ELISA
    • Reactivity:Human;Mouse;Rat
      • Target:
      • BMP-7
      • Fields:
      • >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Axon guidance;>>Hippo signaling pathway
      • Gene Name:
      • BMP7
      • Protein Name:
      • Bone morphogenetic protein 7
      • Human Gene Id:
      • 655
      • Human Swiss Prot No:
      • P18075
      • Mouse Swiss Prot No:
      • P23359
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human BMP-7. AA range:124-173
      • Specificity:
      • BMP-7 Polyclonal Antibody detects endogenous levels of BMP-7 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • BMP7;OP1;Bone morphogenetic protein 7;BMP-7;Osteogenic protein 1;OP-1;Eptotermin alfa
      • Observed Band(KD):
      • 55kD
      • Background:
      • This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016],
      • Function:
      • function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 7 entry,pharmaceutical:Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.,PTM:Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.,tissue specificity:Expressed in the kidneys and bladder. Lower levels seen in the brain.,
      • Subcellular Location:
      • Secreted.
      • Expression:
      • Expressed in the kidney and bladder. Lower levels seen in the brain.
      • Products Images
      • Western Blot analysis of various cells using BMP-7 Polyclonal Antibody diluted at 1:500
      • Western Blot analysis of rat-musle cells using BMP-7 Polyclonal Antibody diluted at 1:500
      • Immunohistochemistry analysis of BMP-7 antibody in paraffin-embedded human tonsil tissue.
      • Western blot analysis of lysate from Jurkat cells, using BMP-7 antibody.