• Target：
• ATPBD3

• Fields：
• >>Sulfur relay system

• Gene Name：
• CTU1

• Protein Name：
• Cytoplasmic tRNA 2-thiolation protein 1

• Human Gene Id：
• 90353

• Human Swiss Prot No：
• Q7Z7A3

• Mouse Swiss Prot No：
• Q99J10

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ATPBD3. AA range:291-340

• Specificity：
• ATPBD3 Polyclonal Antibody detects endogenous levels of ATPBD3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CTU1;ATPBD3;NCS6;Cytoplasmic tRNA 2-thiolation protein 1;ATP-binding domain-containing protein 3;Cancer-associated gene protein;Cytoplasmic tRNA adenylyltransferase 1

• Observed Band(KD)：
• 36kD

• Background：
• function:Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.,pathway:tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.,similarity:Belongs to the ttcA family. CTU1/NCS6/ATPBD3 subfamily.,subunit:Component of a complex at least composed of URM1, CTU2/NCS2 and ATPBD3/NCS6. May for a heterodimer with CTU2/NCS2.,

• Function：
• function:Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.,pathway:tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.,similarity:Belongs to the ttcA family. CTU1/NCS6/ATPBD3 subfamily.,subunit:Component of a complex at least composed of URM1, CTU2/NCS2 and ATPBD3/NCS6. May for a heterodimer with CTU2/NCS2.,

• Subcellular Location：
• Cytoplasm.

• Expression：
• Brain,Epithelium,Teratocarcinoma,

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