• Target：
• AR-β3

• Fields：
• >>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>Neuroactive ligand-receptor interaction;>>Thermogenesis;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Salivary secretion;>>Chemical carcinogenesis - receptor activation

• Gene Name：
• ADRB3

• Protein Name：
• Beta-3 adrenergic receptor

• Human Gene Id：
• 155

• Human Swiss Prot No：
• P13945

• Mouse Gene Id：
• 11556

• Mouse Swiss Prot No：
• P25962

• Rat Gene Id：
• 25645

• Rat Swiss Prot No：
• P26255

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ADRB3. AA range:250-299

• Specificity：
• AR-β3 Polyclonal Antibody detects endogenous levels of AR-β3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ADRB3;ADRB3R;B3AR;Beta-3 adrenergic receptor;Beta-3 adrenoreceptor;Beta-3 adrenoceptor

• Observed Band(KD)：
• 36kD

• Background：
• The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009],

• Function：
• function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.,polymorphism:The variant Arg-64 seems to be associated with weight gain (obesity) and to is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed mainly in adipose tissues.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Expressed mainly in adipose tissues.

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