• Target：
• ARHGEF10

• Gene Name：
• ARHGEF10

• Protein Name：
• Rho guanine nucleotide exchange factor 10

• Human Gene Id：
• 9639

• Human Swiss Prot No：
• O15013

• Mouse Swiss Prot No：
• Q8C033

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ARHGEF10. AA range:339-388

• Specificity：
• ARHGEF10 Polyclonal Antibody detects endogenous levels of ARHGEF10 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ARHGEF10;KIAA0294;Rho guanine nucleotide exchange factor 10

• Observed Band(KD)：
• 152kD

• Background：
• This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],

• Function：
• disease:Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.,function:May play a role in developmental myelination of peripheral nerves.,sequence caution:Cloning artifact.,sequence caution:Translated as Lys.,similarity:Contains 1 DH (DBL-homology) domain.,

• Subcellular Location：
• centrosome,cytosol,

• Expression：
• Amygdala,Brain,Duodenum,Prostate,Testis,Uterus,

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