• Target：
• AR α2B

• Fields：
• >>cGMP-PKG signaling pathway;>>Neuroactive ligand-receptor interaction

• Gene Name：
• ADRA2B

• Protein Name：
• Alpha-2B adrenergic receptor

• Human Gene Id：
• 151

• Human Swiss Prot No：
• P18089

• Mouse Swiss Prot No：
• P30545

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor alpha-2B. AA range:161-210

• Specificity：
• AR α2B Polyclonal Antibody detects endogenous levels of AR α2B protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ADRA2B;ADRA2L1;ADRA2RL1;Alpha-2B adrenergic receptor;Alpha-2 adrenergic receptor subtype C2;Alpha-2B adrenoreceptor;Alpha-2B adrenoceptor;Alpha-2BAR

• Molecular Weight(Da)：
• 50kD

• Background：
• This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014],

• Function：
• function:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.,polymorphism:A rare polymorphic framshift in position 451 produces a protein of 542 residues.,similarity:Belongs to the G-protein coupled receptor 1 family.,

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein . Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. .

• Expression：
• Pooled,

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