• Target：
• ApoL3

• Gene Name：
• APOL3

• Protein Name：
• Apolipoprotein L3

• Human Gene Id：
• 80833

• Human Swiss Prot No：
• O95236

• Immunogen：
• Synthesized peptide derived from ApoL3 . at AA range: 100-180

• Specificity：
• ApoL3 Polyclonal Antibody detects endogenous levels of ApoL3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• APOL3;Apolipoprotein L3;Apolipoprotein L-III;ApoL-III;TNF-inducible protein CG12-1;CG12_1

• Molecular Weight(Da)：
• 44kD

• Background：
• This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015],

• Function：
• function:May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.,induction:In vitro, is responsive to tumor necrosis factor.,similarity:Belongs to the apolipoprotein L family.,tissue specificity:Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and testis.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and testis.

Apolipoprotein L3 inhibits breast cancer proliferation and modulates cell cycle via the P53 pathway Journal of Cancer Yu Hao IF Human MCF7 cell

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