• Target：
• APHC

• Fields：
• >>Sphingolipid metabolism;>>Metabolic pathways

• Gene Name：
• ACER3

• Protein Name：
• Alkaline ceramidase 3

• Human Gene Id：
• 55331

• Human Swiss Prot No：
• Q9NUN7

• Mouse Gene Id：
• 66190

• Mouse Swiss Prot No：
• Q9D099

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human PHCA. AA range:171-220

• Specificity：
• APHC Polyclonal Antibody detects endogenous levels of APHC protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ACER3;APHC;PHCA;Alkaline ceramidase 3;AlkCDase 3;Alkaline CDase 3;Alkaline dihydroceramidase SB89;Alkaline phytoceramidase;aPHC

• Observed Band(KD)：
• 35kD

• Background：
• enzyme regulation:Activated by Ca(2+) and inhibited by Zn(2+).,function:Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.,similarity:Belongs to the alkaline ceramidase family.,tissue specificity:Ubiquitously expressed. Highest expression in placenta.,

• Function：
• enzyme regulation:Activated by Ca(2+) and inhibited by Zn(2+).,function:Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.,similarity:Belongs to the alkaline ceramidase family.,tissue specificity:Ubiquitously expressed. Highest expression in placenta.,

• Subcellular Location：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .

• Expression：
• Ubiquitously expressed. Highly expressed in placenta (PubMed:11356846). Expressed in erythrocytes (PubMed:20207939).

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