APC5 Polyclonal Antibody

    • Catalog No.:YT0262
    • Applications:WB;ELISA
    • Reactivity:Human;Rat;Mouse;
      • Target:
      • APC5
      • Fields:
      • >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>IL-17 signaling pathway;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection
      • Gene Name:
      • ANAPC5
      • Protein Name:
      • Anaphase-promoting complex subunit 5
      • Human Swiss Prot No:
      • Q9UJX4
      • Mouse Swiss Prot No:
      • Q8BTZ4
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human ANAPC5. AA range:151-200
      • Specificity:
      • APC5 Polyclonal Antibody detects endogenous levels of APC5 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • ANAPC5;APC5;Anaphase-promoting complex subunit 5;APC5;Cyclosome subunit 5
      • Observed Band(KD):
      • 85kD
      • Background:
      • This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008],
      • Function:
      • function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the APC5 family.,similarity:Contains 4 TPR repeats.,subunit:The APC/C is composed of at least 11 subunits.,
      • Subcellular Location:
      • Nucleus . Cytoplasm, cytoskeleton, spindle .
      • Expression:
      • Brain,Cerebellum,Cervix,Epithelium,Lung,Oesophagus,Periodontal liga
      • Products Images
      • Western Blot analysis of various cells using APC5 Polyclonal Antibody
      • Western blot analysis of the lysates from HeLa cells using ANAPC5 antibody.