• Target：
• AKAP 10

• Gene Name：
• AKAP10

• Protein Name：
• A-kinase anchor protein 10 mitochondrial

• Human Gene Id：
• 11216

• Human Swiss Prot No：
• O43572

• Mouse Gene Id：
• 56697

• Mouse Swiss Prot No：
• O88845

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human AKAP10. AA range:10-59

• Specificity：
• AKAP 10 Polyclonal Antibody detects endogenous levels of AKAP 10 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• AKAP10;A-kinase anchor protein 10; mitochondrial;AKAP-10;Dual specificity A kinase-anchoring protein 2;D-AKAP-2;Protein kinase A-anchoring protein 10;PRKA10

• Observed Band(KD)：
• 73kD

• Background：
• This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012],

• Function：
• domain:RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.,function:Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.,similarity:Contains 2 RGS domains.,s

• Subcellular Location：
• Mitochondrion . Membrane . Cytoplasm . Predominantly mitochondrial but also membrane associated and cytoplasmic.

• Expression：
• Brain,Lung,

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