• Target：
• ADAMTS-16

• Gene Name：
• ADAMTS16

• Protein Name：
• A disintegrin and metalloproteinase with thrombospondin motifs 16

• Human Gene Id：
• 170690

• Human Swiss Prot No：
• Q8TE57

• Mouse Gene Id：
• 271127

• Mouse Swiss Prot No：
• Q69Z28

• Immunogen：
• Synthesized peptide derived from ADAMTS-16 . at AA range: 440-520

• Specificity：
• ADAMTS-16 Polyclonal Antibody detects endogenous levels of ADAMTS-16 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ADAMTS16;KIAA2029;A disintegrin and metalloproteinase with thrombospondin motifs 16;ADAM-TS 16;ADAM-TS16;ADAMTS-16

• Molecular Weight(Da)：
• 136kD

• Background：
• This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016],

• Function：
• cofactor:Binds 1 zinc ion per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 6 TSP type-1 domains.,tissue specificity:Expressed in fetal lung and kidney and in adult prostate and ovary.,

• Subcellular Location：
• Secreted, extracellular space, extracellular matrix .

• Expression：
• Expressed in fetal lung and kidney and in adult prostate and ovary.

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