• Target：
• ACTR-IIA

• Fields：
• >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>Fluid shear stress and atherosclerosis

• Gene Name：
• ACVR2A

• Protein Name：
• Activin receptor type-2A

• Human Gene Id：
• 92

• Human Swiss Prot No：
• P27037

• Mouse Gene Id：
• 11480

• Mouse Swiss Prot No：
• P27038

• Rat Gene Id：
• 29263

• Rat Swiss Prot No：
• P38444

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ACTR-IIA. AA range:10-59

• Specificity：
• ACTR-IIA Polyclonal Antibody detects endogenous levels of ACTR-IIA protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ACVR2A;ACVR2;Activin receptor type-2A;Activin receptor type IIA;ACTR-IIA;ACTRIIA

• Observed Band(KD)：
• 48kD

• Background：
• This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013],

• Function：
• catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.,

• Subcellular Location：
• Membrane; Single-pass type I membrane protein.

• Expression：
• Mammary gland,Testis,

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