• Target：
• ACTR-IB

• Fields：
• >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells

• Gene Name：
• ACVR1B

• Protein Name：
• Activin receptor type-1B

• Human Gene Id：
• 91

• Human Swiss Prot No：
• P36896

• Mouse Gene Id：
• 11479

• Mouse Swiss Prot No：
• Q61271

• Rat Gene Id：
• 29381

• Rat Swiss Prot No：
• P80202

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ACV1B. AA range:73-122

• Specificity：
• ACTR-IB Polyclonal Antibody detects endogenous levels of ACTR-IB protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ACVR1B;ACVRLK4;ALK4;Activin receptor type-1B;Activin receptor type IB;ACTR-IB;Activin receptor-like kinase 4;ALK-4;Serine/threonine-protein kinase receptor R2;SKR2

• Observed Band(KD)：
• 56kD

• Background：
• This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010],

• Function：
• catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TTRAP.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.,similarity:Contains 1 GS domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Interacts with TTRAP.,tissue specificity:Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.

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