• Target：
• ABCC12

• Fields：
• >>ABC transporters

• Gene Name：
• ABCC12

• Protein Name：
• Multidrug resistance-associated protein 9

• Human Gene Id：
• 94160

• Human Swiss Prot No：
• Q96J65

• Mouse Swiss Prot No：
• Q80WJ6

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MRP9. AA range:691-740

• Specificity：
• ABCC12 Polyclonal Antibody detects endogenous levels of ABCC12 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ABCC12;MRP9;Multidrug resistance-associated protein 9;ATP-binding cassette sub-family C member 12

• Observed Band(KD)：
• 170kD

• Background：
• This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008],

• Function：
• developmental stage:Expressed in fetal tissues.,function:Probable transporter.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells.,

• Subcellular Location：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein .

• Expression：
• Expressed in testis (at protein level). Widely expressed at low level (PubMed:11483364, PubMed:11688999, PubMed:12011458, PubMed:17472575). Isoform 5 is specifically expressed in brain, testis and breast cancer cells (PubMed:11483364, PubMed:11688999, PubMed:12011458).

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