• Target：
• ABCA6

• Fields：
• >>ABC transporters

• Gene Name：
• ABCA6

• Protein Name：
• ATP-binding cassette sub-family A member 6

• Human Gene Id：
• 23460

• Human Swiss Prot No：
• Q8N139

• Mouse Swiss Prot No：
• Q8K441

• Immunogen：
• Synthesized peptide derived from ABCA6 . at AA range: 1180-1260

• Specificity：
• ABCA6 Polyclonal Antibody detects endogenous levels of ABCA6 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ABCA6;ATP-binding cassette sub-family A member 6

• Observed Band(KD)：
• 185kD

• Background：
• The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. [provided by RefSeq, Jul 2008],

• Function：
• developmental stage:Expressed in fetal kidney, lung and liver.,function:Probable transporter which may play a role in macrophage lipid homeostasis.,induction:Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages.,similarity:Belongs to the ABC transporter family. ABCA subfamily.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Widely expressed with higher expression in liver.,

• Subcellular Location：
• Golgi apparatus membrane ; Multi-pass membrane protein .

• Expression：
• Widely expressed with higher expression in liver.

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