• Target：
• AASD-PPT

• Fields：
• >>Pantothenate and CoA biosynthesis;>>Metabolic pathways

• Gene Name：
• AASDHPPT

• Protein Name：
• L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

• Human Gene Id：
• 60496

• Human Swiss Prot No：
• Q9NRN7

• Mouse Gene Id：
• 67618

• Mouse Swiss Prot No：
• Q9CQF6

• Rat Gene Id：
• 300328

• Rat Swiss Prot No：
• B2RYJ4

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human AASDHPPT. AA range:11-60

• Specificity：
• AASD-PPT Polyclonal Antibody detects endogenous levels of AASD-PPT protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• AASDHPPT;CGI-80;HAH-P;HSPC223;x0005;L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase;4'-phosphopantetheinyl transferase;Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase;AASD-PPT;

• Observed Band(KD)：
• 36kD

• Background：
• The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:CoA-[4'-phosphopantetheine] + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].,cofactor:Binds 1 magnesium ion.,function:Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the P-Pant transferase superfamily. AcpS family.,subunit:Monomer. Interacts with FASN.,tissue specificity:Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.,

• Subcellular Location：
• Cytoplasm, cytosol .

• Expression：
• Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.

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