• Target：
• Csk

• Fields：
• >>Epithelial cell signaling in Helicobacter pylori infection

• Gene Name：
• CSK

• Protein Name：
• Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)

• Sequence：
• P41240

• Human Gene Id：
• 1445

• Human Swiss Prot No：
• P41240

• Mouse Gene Id：
• 12988

• Mouse Swiss Prot No：
• P41241

• Rat Gene Id：
• 315707

• Rat Swiss Prot No：
• P32577

• Immunogen：
• Synthesized peptide derived from human CSK (Phospho Tyr304)

• Specificity：
• This antibody detects endogenous levels of CSK (Phospho Tyr304) Rabbit pAb at Human, Mouse,Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

• Source：
• Rabbit,polyclonal

• Dilution：
• WB 1:500-2000 IHC 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)

• Observed Band(KD)：
• 55kD

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,

• Subcellular Location：
• Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .

• Expression：
• Expressed in lung and macrophages.

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