CSK (Phospho Tyr304) Rabbit pAb

    • Catalog No.:YP1858
    • Applications:IHC-p,WB
    • Reactivity:Human, Mouse,Rat
      • Fields:
      • >>Epithelial cell signaling in Helicobacter pylori infection
      • Gene Name:
      • CSK
      • Protein Name:
      • Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
      • Sequence:
      • P41240
      • Human Gene Id:
      • 1445
      • Human Swiss Prot No:
      • P41240
      • Mouse Swiss Prot No:
      • P41241
      • Immunogen:
      • Synthesized peptide derived from human CSK (Phospho Tyr304)
      • Specificity:
      • This antibody detects endogenous levels of CSK (Phospho Tyr304) Rabbit pAb at Human, Mouse,Rat
      • Formulation:
      • Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
      • Source:
      • Rabbit,polyclonal
      • Dilution:
      • WB 1:500-2000 IHC 1:50-200
      • Purification:
      • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
      • Observed Band(KD):
      • 55kD
      • Function:
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,
      • Subcellular Location:
      • Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .
      • Expression:
      • Expressed in lung and macrophages.
      • Products Images
      • Western Blot analysis of 1 MCF-7 cell, 2 LPS 100ng/mL 30min treated ,using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000