QIK/QSK (Phospho Thr175/163) rabbit pAb

    • Catalog No.:YP1716
    • Applications:WB
    • Reactivity:Human;Mouse;Rat
      • Target:
      • QIK/QSK
      • Fields:
      • >>Glucagon signaling pathway
      • Gene Name:
      • SIK1 SIK SNF1LK
      • Protein Name:
      • QIK/QSK (Phospho-Thr175/163)
      • Human Swiss Prot No:
      • P57059
      • Mouse Swiss Prot No:
      • Q60670
      • Immunogen:
      • Synthesized peptide derived from human QIK/QSK (Phospho-Thr175/163)
      • Specificity:
      • This antibody detects endogenous levels of QIK/QSK (Phospho-Thr175/163) at Human, Mouse,Rat
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000
      • Purification:
      • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)
      • Molecular Weight(Da):
      • 86kD
      • Function:
      • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,function:Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosp
      • Subcellular Location:
      • Cytoplasm . Nucleus . Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348).
      • Expression:
      • Fetal lung,Spleen,Testis,
      • Products Images
      • Western Blot analysis of 1 HeLa cell, 2 LPS 100ng/mL 30min treated ,using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000