• Target：
• SCRIB

• Fields：
• >>Hippo signaling pathway;>>Tight junction;>>Human papillomavirus infection;>>Viral carcinogenesis

• Gene Name：
• SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL

• Protein Name：
• Scribble (Ser1220)

• Human Gene Id：
• 23513

• Human Swiss Prot No：
• Q14160

• Mouse Gene Id：
• 105782

• Mouse Swiss Prot No：
• Q80U72

• Immunogen：
• Synthesized phosho peptide around human Scribble (Ser1220)

• Specificity：
• This antibody detects endogenous levels of Human Mouse Scribble (phospho-Ser1220)

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)

• Observed Band(KD)：
• 179kD

• Background：
• This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011],

• Function：
• similarity:Contains 4 PDZ (DHR) domains.,

• Subcellular Location：
• Cell membrane ; Peripheral membrane protein. Cell junction . Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse . Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity). .

• Expression：
• Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).

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