SAMHD1 (Phospho Thr592) rabbit pAb

    • Catalog No.:YP1477
    • Applications:WB
    • Reactivity:Human;Mouse;Rat
      • Target:
      • SAMHD1
      • Fields:
      • >>Viral life cycle - HIV-1;>>Human immunodeficiency virus 1 infection
      • Gene Name:
      • SAMHD1 MOP5
      • Protein Name:
      • SAMHD1 (Thr592)
      • Human Swiss Prot No:
      • Q9Y3Z3
      • Mouse Swiss Prot No:
      • Q60710
      • Immunogen:
      • Synthesized phosho peptide around human SAMHD1 (Thr592)
      • Specificity:
      • This antibody detects endogenous levels of Human Mouse Rat SAMHD1 (phospho-Thr592)
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:1000-2000
      • Purification:
      • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • SAM domain and HD domain-containing protein 1 (EC 3.1.4.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5)
      • Observed Band(KD):
      • 72kD
      • Background:
      • SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1(SAMHD1) Homo sapiens This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010],
      • Function:
      • function:May play a role in mediating proinflammatory responses to TNF-alpha signaling.,induction:By interferon gamma. Up-regulated in TNF-alpha treated lung fibroblasts.,similarity:Contains 1 HD domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,tissue specificity:Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.,
      • Subcellular Location:
      • Nucleus . Chromosome . Localizes to sites of DNA double-strand breaks in response to DNA damage. .
      • Expression:
      • Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes (PubMed:11064105). No expression is seen in brain and thymus (PubMed:11064105).
      • Products Images
      • Western Blot analysis of Hela treated or untreated by LPS lysis, using primary antibody at 1:1000 dilution. Secondary antibody(catalog#:RS23920) was diluted at 1:10000