p95/NBS1 (Phospho Ser343) rabbit pAb

  • Catalog No.：YP1430
  • Applications：WB
  • Reactivity：Human;Mouse
    • Target：
    • p95/NBS1
    • Fields：
    • >>Homologous recombination;>>Cellular senescence
    • Gene Name：
    • NBN NBS NBS1 P95
    • Protein Name：
    • p95/NBS1 (Ser343)
    • Human Gene Id：
    • 4683
    • Human Swiss Prot No：
    • O60934
    • Mouse Swiss Prot No：
    • Q9R207
    • Immunogen：
    • Synthesized phosho peptide around human p95 (Ser343)
    • Specificity：
    • This antibody detects endogenous levels of Human Mouse p95 or NBS1 (phospho-Ser343)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)
    • Observed Band(KD)：
    • 85kD
    • Background：
    • Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008],
    • Function：
    • disease:Defects in NBN are a cause of genetic susceptibility to breast cancer (BC) [MIM:114480]. BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early-onset breast cancer.,disease:Defects in NBN are the cause of Nijmegen breakage syndrome (NBS) [MIM:251260]. NBS is an autosomal recessive syndrome characterized by chromosomal instability, radiation sensitivity, microcephaly, growth retardation, immunodeficiency and predisposition to cancer, particularly to lymphoid malignancies.,disease:Defects in NBN may be associated with aplastic anemia [MIM:609135]. Aplastic anemia is a disease of bone-marrow failure characterized by peripheral pancytopenia and marrow hypoplasia. Most of the cases of aplastic anemia are idiopa
    • Subcellular Location：
    • Nucleus . Nucleus, PML body . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents (PubMed:26438602, PubMed:10783165, PubMed:26215093). Acetylation of 'Lys-5' of histone H2AX (H2AXK5ac) promotes NBN/NBS1 assembly at the sites of DNA damage (PubMed:26438602). .
    • Expression：
    • Ubiquitous (PubMed:9590180). Expressed at high levels in testis (PubMed:9590180).

    Attributes

    • Code：
    • YP1430
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-07-03
    Order

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