Numb (Phospho Ser276) rabbit pAb

  • Catalog No.:YP1424
  • Applications:WB
  • Reactivity:Human;Rat;Mouse;
    • Target:
    • Numb
    • Fields:
    • >>Notch signaling pathway
    • Gene Name:
    • NUMB
    • Protein Name:
    • Numb (Ser276)
    • Human Gene Id:
    • 8650
    • Human Swiss Prot No:
    • P49757
    • Mouse Swiss Prot No:
    • Q9QZS3
    • Immunogen:
    • Synthesized phosho peptide around human Numb (Ser276)
    • Specificity:
    • This antibody detects endogenous levels of Human Numb (phospho-Ser276)
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Polyclonal, Rabbit,IgG
    • Dilution:
    • WB 1:1000-2000
    • Purification:
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name:
    • Protein numb homolog (h-Numb) (Protein S171)
    • Observed Band(KD):
    • 70kD
    • Background:
    • The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
    • Function:
    • function:Implicated in the control of cell fate decisions during development.,PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,sequence caution:Intron retention.,similarity:Contains 1 PID domain.,subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.,
    • Subcellular Location:
    • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. .
    • Expression:
    • B cells,Blood,Brain,Cervix carcinoma,Epithelium,Fetal brain,HeLa cells,Live