Jak1(Phospho Tyr1034/1035) rabbit pAb

    • Catalog No.:YP1373
    • Applications:WB;IHC
    • Reactivity:Human;Mouse;Rat
      • Target:
      • JAK1
      • Fields:
      • >>EGFR tyrosine kinase inhibitor resistance;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Osteoclast differentiation;>>Signaling pathways regulating pluripotency of stem cells;>>NOD-like receptor signaling pathway;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Leishmaniasis;>>Toxoplasmosis;>>Tuberculosis;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Human cytomegalovirus infection;>>Influenza A;>>Human papillomavirus infection;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Coronavirus disease - COVID-19;>>Pathways in cancer;>>Viral carcinogenesis;>>Pancreatic cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer
      • Gene Name:
      • JAK1 JAK1A JAK1B
      • Protein Name:
      • Jak1(Tyr1034/1035)
      • Human Gene Id:
      • 3716
      • Human Swiss Prot No:
      • P23458
      • Mouse Swiss Prot No:
      • P52332
      • Immunogen:
      • Synthesized phosho peptide around human Jak1(Tyr1034 and 1035)
      • Specificity:
      • This antibody detects endogenous levels of Human Mouse Rat Jak1(phospho-Tyr1034 or 1035)
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:200-1000;IHC 1:50-300
      • Purification:
      • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
      • Observed Band(KD):
      • 132kD
      • Background:
      • This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
      • Function:
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specif
      • Subcellular Location:
      • Endomembrane system; Peripheral membrane protein. Wholly intracellular, possibly membrane associated.
      • Expression:
      • Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).